Previously, the worst thing that had ever happened to the Flintstones franchise was its use of Rosie O'Donnell in the live-action edition of the title, but since most folks like to just assume those never happened, that particular abomination unto mine nostrils doth not exist. Yea verily (The only bright spot in the otherwise awful The Flintstones in Viva Rock Vegas prequel is Ms. O'Donnell's absence).
In the animated realm, the worst thing that had ever happened to the show was The Pebbles and Bamm-Bamm Show, a vision of the wacky life of Fred and Wilma's daughter Pebbles and Barney and Betty's son Bamm-Bamm at Bedrock High. The post title comes from what their friend Bad-Luck Schleprock always said just before pointing out what a lousy day it was. In a bit of strange coincidence, Pebbles' voice was supplied by Sally Struthers, who had another job playing the daughter of a blue-collar loudmouth in live-action TV.
But the Pebbles and Bamm-Bamm travesty has now been surpassed, as 20th Century Fox TV and Warner Bros. Television will allow Seth McFarlane, annually a strong competitor for Least Funniest Man Or Voice On Television, to reboot the classic "modern Stone-Age family" according to his own blinkered, vulgar humor-free vision.
Bad-Luck Schleprock was right. This is a miserable day.